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Xanthelasma: Causes, Symptoms, and Treatment

Xanthelasma: Causes, Symptoms, and Treatment

Xanthelasma is a relatively common benign growth that appears as a yellow-white, flat lump of accumulated fatty material. It does not qualify as an actual tumor because it does not involve the abnormal growth of new tissue. However, xanthelasma may serve as an indicator of elevated cholesterol levels, particularly in young individuals. To assess cholesterol levels, a doctor may conduct a blood test. Generally, xanthelasma only requires removal if its appearance becomes bothersome.

What is Xanthelasma?


Xanthelasma, a deposit of yellow patches of cholesterol beneath the skin, typically appears near the inner corner of the eyelid. These flat or slightly raised growths are generally benign but can indicate heart disease. Xanthelasma doesn’t resolve independently, maintain its size, or grow larger. Despite being a harmless bump, it possesses a soft chalky, semi-solid texture. Numerous options for its removal, including surgical procedures, are available.

What Are Cholesterol Deposits?

Xanthelasma: Causes, Symptoms, and Treatment
Cholesterol deposits are skin growths caused by the accumulation of cholesterol. They can appear on different parts of the body, such as the palms, legs, and eyelids. The human body synthesizes cholesterol deposits, including cholesterol and other fatty substances. Cholesterol deposits typically form in areas with excess cholesterol buildup in the bloodstream.

These deposits can occur in various body parts, such as the skin, tendons, and blood vessels. Essential for hormone and vitamin production, cell wall maintenance, and fat metabolism. Diets high in saturated fat stimulate the production of cholesterol, while various lifestyle factors and genetics influence it.

Xanthelasma refers to a medical condition involving cholesterol deposits near the eyelid. Experts recommend initiating treatment early to address the initial lesion and prevent the development of subsequent ones.

Who Does Xanthelasmas Affect?


If individuals notice raised yellow patches near the inner corner of the eyelids, Xanthelasma may be afflicting them. This condition is most commonly associated with elevated cholesterol levels, representing a prevalent cholesterol deposit affecting the skin. These fatty cholesterol deposits settle beneath the skin.

It is advisable to consult a reputable dermatologist to determine the optimal treatment for Xanthelasma. While the condition is rare, individuals with high cholesterol levels are at an increased risk of developing Xanthelasma. Several conditions and factors may predispose individuals to Xanthelasma, including

  • Elevated cholesterol and lipids in the bloodstream
  • Increased susceptibility in middle-aged individuals
  • The higher prevalence among females compared to males
  • Presence of Arcus Senillis on the cornea
  • High blood pressure
  • Chain smoking
  • Obesity

Removing Xanthelasma at home is impossible; appropriate treatment depends on various factors. You should schedule an appointment with a top dermatologist in Dubai for a permanent solution. The expert will guide the removal of xanthelasma, considering the available treatment options.
An experienced dermatologist can diagnose Xanthelasma and determine its underlying cause. Numerous treatment options are available. This can cause infection, scarring, and pain.

When To Consult the Best Dermatologist


While Xanthelasma is harmless, it can also indicate an early cholesterol problem, with plaque accumulating in blood vessels. High cholesterol can block arteries, causing strokes and heart attacks. See a top dermatologist when you notice yellow patches for the best advice on removing Xanthelasma.

Causes Of Xanthelasma


The condition affects many patients, with most having high blood cholesterol levels. In some cases, patients may exhibit normal cholesterol levels. The primary causes of the condition include:

  • Elevated levels of LDL cholesterol
  • Inherited high cholesterol levels
  • Liver disease

How To Diagnose Xanthelasma

Doctors can determine whether you have xanthoma by examining the skin around your eyes. Your doctor may order tests to check the lipid levels in your blood.

Xanthelasma: Causes, Symptoms, and Treatment

Xanthelasma Treatment and Management

Xanthelasma: Causes, Symptoms, and Treatment
Xanthelasma, which is typically asymptomatic, often prompts individuals to seek treatment for cosmetic reasons. There are several treatment options available to address this condition without duplicating efforts. These include topical application of trichloroacetic acid, cryotherapy using liquid nitrogen, and various laser treatments. Surgical excision has also proven effective in some cases.

It is recommended that patients undergo fasting lipid level assessments. Those diagnosed with hyperlipidemia should undergo a formal cardiovascular risk assessment using appropriate charts. This evaluation helps determine preventive measures. If the xanthelasmas are not bothersome, they can be left untreated. When patients decide to pursue treatment for cosmetic purposes, there are various approaches to consider. Surgical excision can be employed for large lesions with or without skin grafting. Chemical treatment, laser treatment, and cryocautery are also viable options.

In some instances, full-thickness skin grafting obtained through blepharoplasty can be utilized. It is important to note that xanthelasmas may recur following these interventions. While lipid-lowering medication and diet modification have limited or no effect on these lesions, it is important to maintain an overall healthy lifestyle to minimize the risk of cardiovascular disease associated with hyperlipidemia.

Xanthelasma Treatment At Home: Is It Possible?


Removing Xanthelasma at home is impractical as the growths do not disappear spontaneously. They tend to maintain their size or potentially enlarge, necessitating their removal for cosmetic reasons. The Saudi German Skin and Laser Clinic offers various treatment methods for Xanthelasma removal, including;

  • Cryotherapy: freezing the lesions using Liquid Nitrogen
  • Laser Ablation and
  • Surgical Excision
  • Electrodesiccation (destroying lesions with an electric needle)
  • Chemical Cauterization: Application of topical agents like Trichloroacetic acid

What are Xanthomas?

Xanthomas are skin lesions characterized by fat accumulation in macrophages, predominantly within the skin, but rarely occurring in the subcutaneous layer.
Xanthelasma: Causes, Symptoms, and Treatment

Causes and Risk Factors of Xanthomas


Xanthomas are typically associated with lipid metabolism disorders (dyslipidemias) or may occur in histiocytosis. In this context, the focus will be on dyslipidemia.

Xanthomas commonly affect adults, but children with familial hypercholesterolemia can also develop xanthomas. The distribution of xanthomas among different races and sexes depends on the causes.

Types of Dyslipidemias Causing Xanthomas


Dyslipidemias leading to xanthomas can be classified as primary or secondary. Xanthelasmas are the most common type of xanthoma (cholesterol buildup) that affects the skin.

However, only about 1% of people have Xanthelasmas. Xanthomas can be infected between the ages of 20 and 70. Most people get them between the ages of 35 and 55.

Primary Dyslipidemias:


  • Hypercholesterolemia, such as the familial type
  • Combined dyslipidemia, for example, Type III hyperlipoproteinemia
  • Hypertriglyceridemia, including Types I, IV, and V hyperlipoproteinemia
  • Cerebrotendinous xanthomatosis and sitosterolemia

Secondary Dyslipidemias:


  • Obesity
  • Diabetes mellitus and insulin resistance
  • Cholestatic liver disease, such as primary biliary cirrhosis
  • Nephrotic syndrome
  • Medications such as estrogens, tamoxifen, oral retinoids, prednisone, and ciclosporin

Additional Types of Xanthomas


Understanding the causes, risk factors, and types of xanthomas is essential to facilitate proper diagnosis and treatment. Certain specific types of xanthomas are associated with other conditions:

  • Diffuse plane xanthomatosis is linked to paraproteinemia.
  • Xanthoma disseminatum is a rare form of histiocytosis.

Necessity of Lifestyle Changes​


Xanthelasma refers to the visible cholesterol deposits around the eyes, typically causing no discomfort or pain. Attempting Xanthelasma removal at home is futile, as cosmetic reasons require professional removal. After the procedure, swelling and bruising around the eyelids may persist for several weeks. To prevent further deposit formation, an expert dermatologist may recommend lifestyle changes, including:

  • Weight loss
  • Consuming a healthy diet
  • Engaging in regular exercise
  • Reducing alcohol consumption
  • Quitting smoking
  • Taking prescribed medications

Xanthelasma is harmless but may indicate an underlying issue with lipid levels and cholesterol. It can serve as an early warning sign of heart disease. You need medical attention for Xanthelasma removal and should not attempt it at home. If left untreated, the condition may spread.
Like other surgical procedures, a person’s lifestyle choices play a significant role, especially in individuals with elevated lipids. Adopting lifestyle changes will improve existing Xanthelasma lesions and prevent their spread and recurrence. To treat your skin condition, visit a respected Skin and Hair Clinic. A famous skin doctor will help you get rid of Xanthelasma.

Eyelid Basal Cell Carcinoma

Xanthelasma: Causes, Symptoms, and Treatment
Basal cell carcinoma is a type of skin cancer. It commonly grows on the edges of the eyelids, the inner corners of the eyes, and the upper cheeks. To diagnose this condition, the doctor takes a small tissue sample and looks at it under a microscope. Surgical removal is the usual course of action for treating this growth.

Other Cancerous Eyelid Growths


Cancer can also happen on the eyelids, like squamous cell carcinoma, meibomian gland carcinoma, and melanoma. If a growth on the eyelid persists for several weeks without disappearing, a doctor may perform a biopsy. Doctors typically recommend surgical removal for these growths.

It is noteworthy that eyelid tumors can sometimes resemble other eye conditions, like blepharitis and chalazion. Consequently, a doctor usually performs a biopsy on any growths that do not respond to initial xanthelasma treatments.

Does xanthelasma indicate high cholesterol levels?


High cholesterol levels often accompany Xanthelasma, a condition characterized by yellowish patches on the eyelids. Not all people with xanthelasma have high cholesterol, and not all people with high cholesterol get xanthelasma. The accumulation of cholesterol deposits in the skin cells of the eyelids causes Xanthelasma. These deposits appear as small, flat, yellowish bumps or patches. While they are usually painless and harmless, they can be a cosmetic concern for some individuals.

Cholesterol Levels: By age, LDL and HDL


If you notice xanthelasma on your eyelids, it is advisable to consult a doctor to assess your cholesterol levels. Doctors may suggest a blood test to check your lipid profile. This test measures your total cholesterol, LDL (bad) cholesterol, HDL (good) cholesterol, and triglyceride levels. If your cholesterol is high, your doctor may recommend changes like eating healthy, exercising, and quitting smoking. In some cases, doctors may prescribe medication to help lower cholesterol levels.

One of the signs of elevated cholesterol is xanthelasma. Remember that xanthelasma can be a visual indicator to determine whether someone has elevated cholesterol. Regular check-ups and cholesterol monitoring are critical for overall health and avoiding potential problems. If you suspect xanthelasma, visit a doctor to get your cholesterol levels evaluated and discuss xanthelasma treatment options.

How is the diagnosis of xanthelasma made?


A healthcare professional typically diagnoses xanthelasma through a physical examination. During this process, they carefully inspect the affected area, commonly the eyelids, for any yellowish or raised patches. These patches are often soft and may have a slightly waxy appearance. In addition to conducting a physical examination, the healthcare professional will also inquire about your medical history and any symptoms you may be experiencing. They might ask about your family’s medical background, including conditions like high cholesterol or related ailments.

LDL and HDL Cholesterol and Triglycerides


The healthcare professional may order a blood test by measuring your cholesterol levels to confirm the diagnosis. This lipid profile test provides detailed information about your total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels. Once a xanthelasma diagnosis is confirmed and cholesterol levels are assessed, healthcare professionals can develop an appropriate xanthelasma treatment plan.

This may involve lifestyle modifications such as adopting a healthy diet with low saturated fats and cholesterol levels, engaging in regular physical activity, and quitting smoking. In certain situations, doctors may prescribe medication to help decrease cholesterol levels. These medications, like statins, limit the liver’s cholesterol production and facilitate the removal of LDL cholesterol from the bloodstream.

Xanthelasma is an important visible sign indicating high cholesterol levels. However, it should not be solely relied upon for diagnosis. Regular check-ups and monitoring of cholesterol levels are essential to ensure overall health and prevent potential complications.

Xanthelasma Differential Diagnosis

Your healthcare provider may see a yellow rash on the skin around your eyelids. A diagnosis of xanthelasma does not require testing, but your healthcare provider may want to check for cholesterol levels to check for high cholesterol and Thyroid function to see if you have thyroid problems.
Xanthelasma: Causes, Symptoms, and Treatment
In some cases, Syringomas and milia can be mistakenly diagnosed as xanthelasma, leading to the need for careful consideration and differentiation. Syringomas are small bumps found on the lower eyelids and have a skin-colored appearance.

Large milial cysts, on the other hand, are white and spherical. Xanthomas occurring in other body areas may display a more orange-yellow hue. Additionally, it is important to consider a range of differentials for lipid disorders.

Associated Diseases with Xanthelasma


Xanthelasma can either be a localized skin condition unrelated to systemic abnormalities in lipoprotein metabolism or be associated with an increase in cholesterol-rich beta-lipoproteins (LDLs). While some patients with xanthelasma may have normal lipid levels, this is less common in younger patients.

Although such individuals may not be at increased risk of carotid atherosclerosis, they often exhibit other risk factors for cardiovascular disease, such as a higher body mass index (BMI), an increased waist circumference, and elevated LDL-C levels.

Prognosis of Xanthelasma


Xanthelasma itself is a benign condition. The prognosis, however, is influenced by its association with underlying lipid abnormalities and cardiovascular risk factors. The face is the index of the mind, the eyes are the windows to the soul. Dark spots on the face, especially around the eyes, can be a serious problem.

Xanthomas (abbreviation for eyelid xanthomas – XP) refer to bumpy yellow patches around the eyes or in the inner corners of the eyelids. If you have a xanthoma problem, modern xanthoma removal in Dubai is your best choice. This page discusses candidates, side effects, costs, treatments, etc. for this skin condition.

When to Refer 


While surgical excision and cryocautery may be available in particular primary care settings, other xanthelasma treatment options are more likely to necessitate referral to secondary care. If you have this problem, you may be a candidate for this technique. If you want to look your best, consider a modern xanthoma removal treatment that leaves your skin in perfect condition.

People Also Ask

What is xanthelasma?

Xanthelasma, also known as xanthelasma palpebrarum (XP), is a harmless and distinctive yellow growth that emerges either on or near the inner corners of the eyelids adjacent to the nose. These peculiar growths result from the accumulation of cholesterol deposits beneath the skin, forming what is known as xanthelasma.

What are the symptoms of xanthelasma?

The symptoms of xanthelasma manifest as areas of yellowish skin surrounding the eyelids. These areas can vary in appearance, ranging from flat to bumpy, and they may exhibit a soft or firm texture. In certain cases, individuals with xanthelasma may experience a degree of discomfort.

What causes xanthelasma?

Various factors can contribute to the development of xanthelasma. One potential cause is the inheritance of high cholesterol from parents, which can predispose individuals to this condition. Additionally, underlying conditions such as diabetes mellitus, weight gain, thyroid disorders like hypothyroidism, and inflammation have been identified as possible contributing factors. Excessive alcohol consumption has also been linked to the occurrence of xanthelasma.

Does xanthelasma mean you have high cholesterol?

Having xanthelasma often indicates the presence of high cholesterol. While high cholesterol typically does not present noticeable symptoms initially, a blood test can confirm its presence. To bring cholesterol levels back to a normal range, certain lifestyle changes can be adopted. These changes include incorporating a greater amount of vegetables and fruits into one’s diet while reducing the consumption of fatty foods, engaging in regular exercise, and, in some cases, taking cholesterol-lowering medications.

What is the best treatment for Xanthelasmas?

When it comes to the treatment of xanthelasma, seeking assistance from a healthcare professional is highly recommended. Xanthelasma removal conducted by a qualified provider is considered the most effective option. In many cases, healthcare providers prefer utilizing liquid nitrogen cryotherapy as the primary method for removing xanthelasma.

It is important to note that changing to a low-fat diet and taking statins, although beneficial for managing cholesterol, will not eliminate existing xanthelasma. Therefore, seeking professional treatment is crucial for successful removal.

How long does it take to recover from xanthelasma treatment?

The recovery period following xanthelasma treatment varies depending on the specific method employed. Typically, it may take around three to four days to fully recover from the treatment. Some side effects subside within days, while others, such as skin discoloration, may take a couple of months to completely disappear.

When should I see my healthcare provider?

Individuals who undergo xanthelasma removal should attend follow-up appointments with their healthcare providers. The frequency of these check-ups may vary based on the chosen treatment approach. For instance, follow-up appointments might be scheduled one month and three months after the procedure. If any bothersome side effects arise from the xanthelasma treatment, it is advisable to promptly contact the healthcare provider. Additionally, it is important to inform the provider if the xanthelasmas reappear after treatment.

What questions should I ask my doctor?

When consulting a healthcare professional regarding xanthelasma, it is beneficial to ask pertinent questions to gain a comprehensive understanding of the situation. Some recommended questions include inquiring about the most suitable treatment option for the individual’s specific circumstances, the expected duration of recovery for the chosen treatment, the provider’s experience in treating similar cases, and whether it is necessary to undergo screening for high cholesterol and heart disease.